LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007220

UniProt Annotations

Entry Information
Gene Namefatty acid alpha-hydroxylase
Protein EntrySCS7_YEAST
UniProt IDQ03529
SpeciesYeast (S288c)
Comments
Comment typeDescription
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ;
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionCeramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3. {ECO:0000269|PubMed:12006573, ECO:0000269|PubMed:16652392, ECO:0000269|PubMed:19074599, ECO:0000269|PubMed:9353282, ECO:0000269|PubMed:9368039, ECO:0000269|PubMed:9559540}.
MiscellaneousPresent with 3290 molecules/cell in log phase SD medium
MiscellaneousPresent with 3290 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the sterol desaturase family. SCS7 subfamily
SimilarityBelongs to the sterol desaturase family. SCS7 subfamily. {ECO:0000305}.
SimilarityContains 1 cytochrome b5 heme-binding domain
SimilarityContains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .