LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

LMP007236

UniProt Annotations

Entry Information

Gene Name	fatty acid elongase SUR4
Protein Entry	ELO3_YEAST
UniProt ID	P40319
Species	Yeast (S288c)

Comments

Comment type	Description
Catalytic Activity	A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2)
Catalytic Activity	A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2). {ECO:0000269\|PubMed:12684876}.
Domain	The C-terminal di-lysine motifs may confer endoplasmic reticulum localization
Domain	The C-terminal di-lysine motifs may confer endoplasmic reticulum localization. {ECO:0000303\|PubMed:9832547}.
Function	Component of a microsomal membrane bound long-chain fatty acid elongation system, which produces the 20-26-carbon very long-chain fatty acids (VLCFA) from long-chain fatty acid precursors and is involved ceramide and inositol sphingolipid biosynthesis. Component of elongase III, which synthesizes 20-26- carbon fatty acids from 18-carbon-fatty acyl-CoA primers such as stearoyl-CoA by incorporation of malonyl-CoA (PubMed:9211877, PubMed:12684876). Affects plasma membrane H(+)-ATPase activity. May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3 (PubMed:8027068). {ECO:0000269\|PubMed:12684876, ECO:0000269\|PubMed:8027068, ECO:0000269\|PubMed:9211877}.
Similarity	Belongs to the ELO family
Similarity	Belongs to the ELO family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:12087109, ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:9832547}; Multi-pass membrane protein .
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:12087109, ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:9832547}; Multi-pass membrane protein {ECO:0000305}.