LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007298

UniProt Annotations

Entry Information
Gene NamePlb3p
Protein EntryPLB3_YEAST
UniProt IDQ08108
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
FunctionSequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate
FunctionSequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate. {ECO:0000269|PubMed:10497163}.
SimilarityBelongs to the lysophospholipase family
SimilarityBelongs to the lysophospholipase family. {ECO:0000305}.
SimilarityContains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular LocationCell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Subcellular LocationCell membrane ; Lipid-anchor, GPI-anchor .