LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007325

UniProt Annotations

Entry Information
Gene NamePkp2p
Protein EntryPDK2_YEAST
UniProt IDP53170
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + [pyruvate dehydrogenase (acetyl- transferring)] = ADP + [pyruvate dehydrogenase (acetyl- transferring)] phosphate.
FunctionInhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism. {ECO:0000269|PubMed:16319894, ECO:0000269|PubMed:17918780, ECO:0000269|PubMed:18180296}.
InteractionP40530:PKP1; NbExp=3; IntAct=EBI-23792, EBI-2610722;
MiscellaneousPresent with 450 molecules/cell in log phase SD medium
MiscellaneousPresent with 450 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Sequence CautionSequence=CAA96762.1; Type=Frameshift; Positions=435; Evidence= ;
Sequence CautionSequence=CAA96762.1; Type=Frameshift; Positions=435; Evidence={ECO:0000305};
SimilarityBelongs to the PDK/BCKDK protein kinase family
SimilarityBelongs to the PDK/BCKDK protein kinase family. {ECO:0000305}.
SimilarityContains 1 histidine kinase domain
SimilarityContains 1 histidine kinase domain. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:17918780, ECO:0000269|PubMed:18180296}.
SubunitInteracts with PKP1
SubunitInteracts with PKP1. {ECO:0000269|PubMed:18180296}.