LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007390

UniProt Annotations

Entry Information
Gene NamePkp1p
Protein EntryPDK1_YEAST
UniProt IDP40530
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + [pyruvate dehydrogenase (acetyl- transferring)] = ADP + [pyruvate dehydrogenase (acetyl- transferring)] phosphate.
FunctionInhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism. Also involved in telomere maintenance. {ECO:0000269|PubMed:15161972, ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:18180296}.
InteractionP53170:PKP2; NbExp=3; IntAct=EBI-2610722, EBI-23792;
MiscellaneousPresent with 4220 molecules/cell in log phase SD medium
MiscellaneousPresent with 4220 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the PDK/BCKDK protein kinase family
SimilarityBelongs to the PDK/BCKDK protein kinase family. {ECO:0000305}.
SimilarityContains 1 histidine kinase domain
SimilarityContains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00107}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:18180296}.
SubunitInteracts with PKP2
SubunitInteracts with PKP2. {ECO:0000269|PubMed:18180296}.