LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007423

UniProt Annotations

Entry Information
Gene Nameprofilin
Protein EntryPROF_YEAST
UniProt IDP07274
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionBinds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
InteractionQ9VEX9:Bin1 (xeno); NbExp=3; IntAct=EBI-13892, EBI-129424;
SimilarityBelongs to the profilin family
SimilarityBelongs to the profilin family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton.
SubunitOccurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.