LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007647

UniProt Annotations

Entry Information
Gene Name1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Protein EntryISPG_ECOLI
UniProt IDP62620
SpeciesE. coli
Comments
Comment typeDescription
Catalytic Activity(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + 2 oxidized ferredoxin = 2-C-methyl-D- erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. {ECO:0000269|PubMed:12571359}.
CofactorName=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.;
FunctionConverts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
InteractionP77188:ecpB; NbExp=2; IntAct=EBI-550338, EBI-1113651;
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate: step 5/6. {ECO:0000269|PubMed:11163766, ECO:0000269|PubMed:11274098}.
SimilarityBelongs to the IspG family. {ECO:0000305}.