LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007666

UniProt Annotations

Entry Information
Gene Nameperiplasmic membrane-anchored LPS-binding protein; LPS export protein
Protein EntryLPTC_ECOLI
UniProt IDP0ADV9
SpeciesE. coli
Comments
Comment typeDescription
Disruption PhenotypeLeads to irreversible cell damage, growth arrest and an extreme sensitivity to SDS. {ECO:0000269|PubMed:16765569}.
FunctionInvolved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. {ECO:0000255|HAMAP-Rule:MF_01915, ECO:0000269|PubMed:16765569, ECO:0000269|PubMed:18424520, ECO:0000269|PubMed:20720015, ECO:0000269|PubMed:21169485, ECO:0000269|PubMed:21195693}.
InteractionSelf; NbExp=4; IntAct=EBI-1131969, EBI-1131969; P0ADV1:lptA; NbExp=3; IntAct=EBI-1131969, EBI-1132001;
MiscellaneousInteracts with the LptBFG ABC transporter complex, but does not affect its ATPase activity. {ECO:0000305|PubMed:19500581}.
SimilarityBelongs to the LptC family. {ECO:0000255|HAMAP- Rule:MF_01915}.
Subcellular LocationCell inner membrane {ECO:0000255|HAMAP- Rule:MF_01915, ECO:0000269|PubMed:18424520, ECO:0000269|PubMed:20720015}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01915, ECO:0000269|PubMed:18424520, ECO:0000269|PubMed:20720015}.
SubunitComponent of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex. When overexpressed, can form homodimers in vivo. {ECO:0000255|HAMAP-Rule:MF_01915, ECO:0000269|PubMed:19500581, ECO:0000269|PubMed:20446753, ECO:0000269|PubMed:21169485, ECO:0000269|PubMed:21195693, ECO:0000269|PubMed:22668317}.