LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007678

UniProt Annotations

Entry Information
Gene Nameundecaprenyl phosphate-alpha-L-ara4N exporter; flippase ArnEF subunit
Protein EntryARNF_ECOLI
UniProt IDP76474
SpeciesE. coli
Comments
Comment typeDescription
Disruption PhenotypeCells lacking this gene are polymyxin sensitive. Lipid A is no longer modified with L-Ara4N even though the level of the lipid-linked donor of the L-Ara4N moiety, alpha- L-Ara4N-phosphoundecaprenol, is not reduced. However, the alpha-L- Ara4N-phosphoundecaprenol is less concentrated on the periplasmic surface of the inner membrane when compared to wild type. {ECO:0000269|PubMed:17928292}.
FunctionTranslocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane. {ECO:0000269|PubMed:17928292}.
InductionInduced by BasR. {ECO:0000269|PubMed:15569938}.
PathwayBacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Sequence CautionSequence=AAB04894.1; Type=Frameshift; Positions=128; Evidence={ECO:0000305};
SimilarityBelongs to the ArnF family. {ECO:0000305}.
Subcellular LocationCell inner membrane; Multi-pass membrane protein.
SubunitHeterodimer of ArnE and ArnF. {ECO:0000305|PubMed:17928292}.