LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007696

UniProt Annotations

Entry Information
Gene Nameshort chain acyl-CoA synthetase, anaerobic
Protein EntryFADK_ECOLI
UniProt IDP38135
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
FunctionCatalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It has a low activity on medium or long chain fatty acids and is maximally active on C6 and C8 substrates.
InductionExpression independent of FadR. The levels of expression vary with the terminal electron acceptor (nitrate, fumarate). FadK is not expressed under aerobic growth conditions and it could functionally replace FadD under anaerobic conditions.
Sequence CautionSequence=BAA15470.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=M69116; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMembrane; Peripheral membrane protein. Note=Partially membrane-associated.
SubunitHomodimer. {ECO:0000250}.