LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007713

UniProt Annotations

Entry Information
Gene Namebeta-hydroxydecanoyl thioester dehydrase
Protein EntryFABA_ECOLI
UniProt IDP0A6Q3
SpeciesE. coli
Comments
Comment typeDescription
Catalytic Activity(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H(2)O. {ECO:0000269|PubMed:8910376}.
Catalytic ActivityA (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O. {ECO:0000269|PubMed:8910376}.
Catalytic ActivityTrans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein]. {ECO:0000269|PubMed:8910376}.
FunctionNecessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. Is inactive in the dehydration of long chain unsaturated beta-hydroxyacyl-ACP. {ECO:0000269|PubMed:8910376}.
PathwayLipid metabolism; fatty acid biosynthesis.
Sequence CautionSequence=AAA96496.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the thioester dehydratase family. FabA subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer.