LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007834

UniProt Annotations

Entry Information
Gene NameProtein MBOA-7
Protein EntryQ19468_CAEEL
UniProt IDQ19468
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityAcyl-[acyl-carrier-protein] + 1-acyl-sn- glycerol 3-phosphate = [acyl-carrier-protein] + 1,2-diacyl-sn- glycerol 3-phosphate.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylinositol = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylinositol.
Disruption PhenotypeMutants show larval arrest at an early developmental stage and egg-laying defects; 14% of mutants accumulate unlaid eggs that hatched internally.
FunctionAcyltransferase which mediates the conversion of lysophosphatidylinositol (1-acyl-sn-glycero-3-phosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3- phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA or eicosapentaenoic acid (EPA) as the acyl donor. Prefers sn-2-LPI rather than sn-1-LPI as the acyl acceptor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the membrane-bound acyltransferase family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
Tissue SpecificityExpressed ubiquitously throughout development from early embryo to larval and adult stages. In adults, strongly expressed in pharyngeal muscle, body wall muscle, vulval cells, distal tip cells, intestinal cells and spermatheca.