LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007848

UniProt Annotations

Entry Information
Gene NameProtein SPTL-1
Protein EntrySPTC1_CAEEL
UniProt IDP91079
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
FunctionComponent of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. {ECO:0000250, ECO:0000269|PubMed:21926990}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
SubunitHeterodimer of sptl-1/sptl-2 or sptl-1/sptl-3. {ECO:0000250}.