LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007862

UniProt Annotations

Entry Information
Gene NameProtein NCR-2
Protein EntryNPC2_CAEEL
UniProt IDP34389
SpeciesC. elegans
Comments
Comment typeDescription
Disruption PhenotypeBoth ncr-1 single mutant and ncr-1 and ncr-2 double mutants exhibit slow embryonic and larval development, and hyperactive egg-laying behavior (egg-laying constitutive (egl-c) phenotype). Ncr-1 and ncr-2 double mutants inappropriately and transiently form dauer larvae under favorable conditions (dauer- constitutive (daf-c) phenotype). {ECO:0000269|PubMed:10801441}.
FunctionInvolved in the uptake or utilization of cholesterol. Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. {ECO:0000269|PubMed:10801441}.
SimilarityBelongs to the patched family. {ECO:0000305}.
SimilarityContains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.