LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007868

UniProt Annotations

Entry Information
Gene NameProtein ELO-5
Protein EntryELO5_CAEEL
UniProt IDQ20300
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2). {ECO:0000269|PubMed:15340492}.
Disruption PhenotypeLoss of function induces an egg-laying defect from the second day of adulthood with progeny arrested at the larval stage L1. The small larvae maintain morphological integrity and survive for up to 3 to 4 days. Animals had reduced levels of isoheptadecanoate (C17iso) and isopentadecanoate (C15iso). The phenotype could be fully suppressed by feeding with C17iso and partially suppressed by feeding with C15iso. {ECO:0000269|PubMed:15340492}.
FunctionCondensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). {ECO:0000269|PubMed:15340492}.
PathwayLipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:15340492}.
SimilarityBelongs to the ELO family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in the gut and unidentified head cells. {ECO:0000269|PubMed:15340492}.