LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007887

UniProt Annotations

Entry Information
Gene NameProtein HYL-2
Protein EntryHYL2_CAEEL
UniProt IDQ7Z139
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + sphingosine = CoA + N- acylsphingosine. {ECO:0000269|PubMed:19372430}.
FunctionCatalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. {ECO:0000269|PubMed:19372430}.
PathwayLipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:19372430}.
SimilarityBelongs to the sphingosine N-acyltransferase family. {ECO:0000305}.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.