LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007899

UniProt Annotations

Entry Information
Gene NameProtein CGT-2
Protein EntryCGT2_CAEEL
UniProt IDG5EC84
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityUDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine. {ECO:0000269|PubMed:11443131, ECO:0000269|PubMed:21325339}.
Disruption PhenotypeReduced brood size
Disruption PhenotypeReduced brood size. {ECO:0000269|PubMed:21325339}.
FunctionCatalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. {ECO:0000269|PubMed:11443131, ECO:0000269|PubMed:21325339}.
PathwayLipid metabolism; sphingolipid metabolism
PathwayLipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:11443131, ECO:0000269|PubMed:21325339}.
SimilarityBelongs to the glycosyltransferase 2 family
SimilarityBelongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Subcellular LocationMembrane ; Multi-pass membrane protein .