LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP007943

UniProt Annotations

Entry Information
Gene NameProtein CGT-3
Protein EntryCGT3_CAEEL
UniProt IDQ21054
SpeciesC. elegans
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=a; IsoId=Q21054-1; Sequence=Displayed; Name=b; IsoId=Q21054-2; Sequence=VSP_045384; Name=c; IsoId=Q21054-3; Sequence=VSP_045384, VSP_045385, VSP_045386; Name=d; IsoId=Q21054-4; Sequence=VSP_045383;
Catalytic ActivityUDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine. {ECO:0000269|PubMed:21325339}.
Disruption PhenotypeReduced brood size. Reduced glucosyl- ceramide content and expression at cell surface. Increased expression of sphingomyelins and sphingomyelin clustering at cell surface. Loss of function in the germline leads to defects in oocyte formation and early embryonic divisions and shortened body length. Loss of function in somatic cells may lead to L1 arrest. {ECO:0000269|PubMed:21325339}.
FunctionCatalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Seems to be the major active form in the nematode. {ECO:0000269|PubMed:21325339}.
PathwayLipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:21325339}.
SimilarityBelongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.