LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP008034

UniProt Annotations

Entry Information
Gene NameProtein NCR-1
Protein EntryQ19127_CAEEL
UniProt IDQ19127
SpeciesC. elegans
Comments
Comment typeDescription
Disruption PhenotypeBoth ncr-1 single mutant and ncr-1 and ncr-2 double mutants exhibit slow embryonic and larval development, and hyperactive egg-laying behavior (egg-laying constitutive (egl-c) phenotype). Ncr-1 and ncr-2 double mutants inappropriately and transiently form dauer larvae under favorable conditions (dauer- constitutive (daf-c) phenotype).
FunctionInvolved in the uptake or utilization of cholesterol. Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons.
SimilarityBelongs to the patched family.
SimilarityContains 1 SSD (sterol-sensing) domain.
Subcellular LocationMembrane; Multi-pass membrane protein.