LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

LMP009036

UniProt Annotations

Entry Information

Gene Name	metabotropic Glutamate Receptor
Protein Entry	GRM_DROME
UniProt ID	X2JBI2
Species	Drosophila

Comments

Comment type	Description
Developmental Stage	Expressed in the CNS of the late embryo. {ECO:0000269\|PubMed:8824309}.
Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. {ECO:0000269\|PubMed:10821630, ECO:0000269\|PubMed:8824309}.
Similarity	Belongs to the G-protein coupled receptor 3 family. {ECO:0000305}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:8824309}; Multi-pass membrane protein {ECO:0000269\|PubMed:8824309}.
Tissue Specificity	Expressed in the neurons of the larval CNS from the beginning of the first until the third instar. Expression in the third-instar larval CNS is restricted to a discrete number of somas and projections in the brain lobes and in the ventral ganglion. In the ventral nerve cord, expression is detected both in somas and projections. Expressed in the antennal lobes, the optic lobes, the central complex and the median bundle in the adult CNS. {ECO:0000269\|PubMed:11536189}.