LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP009111

UniProt Annotations

Entry Information
Gene NameCG7840 gene product from transcript CG7840-RA
Protein EntryPORED_DROME
UniProt IDQ9VLP9
SpeciesDrosophila
Comments
Comment typeDescription
Catalytic ActivityDitrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH.
FunctionPlays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). {ECO:0000250}.
InteractionQ9XYQ2:unc-119; NbExp=1; IntAct=EBI-88569, EBI-127298;
PathwayProtein modification; protein glycosylation.
Sequence CautionSequence=AAM52687.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.