LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP009692

UniProt Annotations

Entry Information
Gene Name3-ketoacyl-CoA synthase 10
Protein EntryKCS10_ARATH
UniProt IDQ570B4
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Developmental StageExpressed in prefusion carpel abaxial and adaxial epidermis. Accumulates in ovule primordia, but restricted to chalaza in mature ovules. Also present in cells of stigmatic papillae, at the margins of ovules, and around the embryo sac. {ECO:0000269|PubMed:10559443, ECO:0000269|PubMed:10655527}.
Disruption PhenotypeIn additions to several malformations due to organ fusion, plants lacking FDH demonstrate an enhanced cell wall permeability, reduced trichome formation, and are female sterile. {ECO:0000269|PubMed:10559443}.
FunctionContributes to cuticular wax and suberin biosynthesis. Prevents the postgenital fusion of epiderm cells in organs in contact, as well as ectopic pollen hydration and germination. Required during ovules formation. May regulate an epidermis- specific developmental program during gynoecial ontogeny. {ECO:0000269|PubMed:10559443, ECO:0000269|PubMed:10655527, ECO:0000269|PubMed:1644226, ECO:0000269|PubMed:8416837, ECO:0000269|PubMed:9299123, ECO:0000269|PubMed:9611177}.
InductionRepressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
MiscellaneousCalled 'FIDDLEHEAD' because of the shape of mutants, in which adhering floral buds cause curling of inflorescence, resulting in structures reminiscent of fern fiddlehead.
PathwayLipid metabolism; fatty acid biosynthesis.
Sequence CautionSequence=BAD94049.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the chalcone/stilbene synthases family. {ECO:0000305}.
SimilarityContains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityMostly expressed in epidermal cells of floral and vegetative meristems and, to a lower extent, of leaves and coleoptiles, especially in young tissues. Also present in trichomes and phloem. {ECO:0000269|PubMed:10559443, ECO:0000269|PubMed:10655527}.