LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP009699

UniProt Annotations

Entry Information
Gene Name3-ketoacyl-CoA synthase 18
Protein EntryKCS18_ARATH
UniProt IDQ38860
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Catalytic ActivityStearoyl-CoA + malonyl-CoA + 2 NAD(P)H = icosanoyl-CoA + CO(2) + CoA + 2 NAD(P)(+) + H(2)O.
Developmental StageAccumulates in upper part of roots, hypocotyls and cotyledons of developing embryo. Levels increase in early stages (torpedo, 4 days after flowering) and decrease during late stages of embryo development. {ECO:0000269|PubMed:11575726}.
Enzyme RegulationInhibited by K3 herbicides such as allidochlor, cafenstrole and flufenacet. {ECO:0000269|PubMed:15277688}.
FunctionContributes to fatty acids elongation and stockage in developing seeds. Active on both saturated and mono-unsaturated acyl-CoAs of 16 and 18 carbons. Required for the elongation of C18 to C20 and of C20 to C22 fatty acids. Mediates also the synthesis of VLCFAs from 20 to 26 carbons in length (e.g. C20:1, C20, C22:1, C22, C24:1, C24, C26). {ECO:0000269|PubMed:15277688, ECO:0000269|PubMed:16765910, ECO:0000269|PubMed:7734965, ECO:0000269|PubMed:9263455, ECO:0000269|Ref.4, ECO:0000269|Ref.5}.
InductionRepressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the chalcone/stilbene synthases family. {ECO:0000305}.
SimilarityContains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed specifically in seeds, especially in embryos. {ECO:0000269|PubMed:11575726, ECO:0000269|PubMed:7734965}.