LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP009706

UniProt Annotations

Entry Information
Gene Name3-ketoacyl-CoA synthase 6
Protein EntryKCS6_ARATH
UniProt IDQ9XF43
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9XF43-1; Sequence=Displayed; Name=2; IsoId=Q9XF43-2; Sequence=VSP_022340, VSP_022341; Note=Derived from EST data. No experimental confirmation available.;
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2). {ECO:0000269|PubMed:10330468}.
Disruption PhenotypePlants have no wax crystals and are male sterile. {ECO:0000269|PubMed:10330468}.
FunctionContributes to cuticular wax and suberin biosynthesis. Involved in both decarbonylation and acyl-reduction wax synthesis pathways. Required for elongation of C24 fatty acids, an essential step of the cuticular wax production. {ECO:0000269|PubMed:10330468}.
InductionRepressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
PathwayLipid metabolism; fatty acid biosynthesis.
PtmUbiquitinated. {ECO:0000269|PubMed:19292762}.
Sequence CautionSequence=BAD94789.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the chalcone/stilbene synthases family. {ECO:0000305}.
SimilarityContains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityIn epidermal cells of aerial tissues. {ECO:0000269|PubMed:10330468}.