LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP010081

UniProt Annotations

Entry Information
Gene Namecytochrome P450 86A2
Protein EntryC86A2_ARATH
UniProt IDO23066
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityRH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Developmental StageExpressed in the seed coat inner integument layer facing the endosperm in the stages from globular to torpedo embryo. {ECO:0000269|PubMed:18179651}.
Disruption PhenotypeNo visible phenotype under normal growth conditions, but mutant plants have reduced content of cutin, loose cuticle membrane ultrastructure, show increased permeability to water vapor and display enhanced disease severity to a virulent strain of the bacterial pathogen P.syringae. {ECO:0000269|PubMed:15241470}.
FunctionCatalyzes the omega-hydroxylation of various fatty acids (FA). Acts on saturated and unsaturated fatty acids with chain lengths from C12 to C18. Plays a major role in the biosynthesis of extracellular lipids. Involved in the biosynthesis of hydroxylated fatty acids required for cutin biosynthesis, cuticle development and repression of bacterial type III gene expression. {ECO:0000269|PubMed:15241470, ECO:0000269|PubMed:15709153, ECO:0000269|PubMed:17427946}.
InductionBy abscisic acid (ABA), auxin, wounding and drought, and in etiolated and dark-adapted seedlings. {ECO:0000269|PubMed:15709153, ECO:0000269|PubMed:19704826}.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in leaves, stems, flowers and siliques. Expressed at low levels in roots. Expressed in guard cells of cotyledons and leaves. {ECO:0000269|PubMed:15709153, ECO:0000269|PubMed:19704826}.