LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP010118

UniProt Annotations

Entry Information
Gene NameFatty acid/sphingolipid desaturase
Protein EntrySLD2_ARATH
UniProt IDQ3EBF7
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityPhytosphinganine + reduced acceptor + O(2) = Delta(8)-phytosphingenine + acceptor + 2 H(2)O. {ECO:0000269|PubMed:22023480}.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
Disruption PhenotypeNo visible phenotype under normal growth conditions, but mutant plants show enhanced sensitivity to prolonged low-temperature exposure. {ECO:0000269|PubMed:22023480}.
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding. {ECO:0000250}.
FunctionPlays a minor role as delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in 20-carbon fatty acids that have an existing delta-11 unsaturation. Involved in the biosynthesis of sphingolipids by catalyzing the formation of unsaturated sphongoid long-chain bases (LCB). This structural modification contributes to the quantitative partitioning of ceramides between the two major sphingolipid classes, glucosylceramides and glycosylinositolphosphoryl ceramides. Sphingolipids are important membrane components involved in environmental stress responses, such as resistance to chilling, and act as cell signaling molecules. {ECO:0000269|PubMed:22023480}.
Sequence CautionSequence=AK228217; Type=Frameshift; Positions=16; Evidence={ECO:0000305};
SimilarityBelongs to the fatty acid desaturase family. {ECO:0000305}.
SimilarityContains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305|PubMed:22023480}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityHighly expressed in flowers and siliques. Expressed at low levels in roots, leaves and stems. {ECO:0000269|PubMed:22023480}.