LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP010160

UniProt Annotations

Entry Information
Gene Namedolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Protein EntrySTT3A_ARATH
UniProt IDQ93ZY3
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityDolichyl diphosphooligosaccharide + [protein]- L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
Disruption PhenotypeSalt/osmotic sensitivity associated with root tip growth arrest and swelling and the induction of lateral roots. {ECO:0000269|PubMed:12972670}.
FunctionCatalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity (By similarity). Controls adaptive responses to salt/osmotic stress. Acts as a key glycosylation determinant for EFR function during plant innate immunity. {ECO:0000250, ECO:0000269|PubMed:12972670, ECO:0000269|PubMed:19763086, ECO:0000269|PubMed:19763087}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the STT3 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:16618929, ECO:0000269|PubMed:22923678}; Multi- pass membrane protein {ECO:0000269|PubMed:16618929, ECO:0000269|PubMed:22923678}.
SubunitComponent of the oligosaccharyltransferase (OST) complex. {ECO:0000250}.
Tissue SpecificityExpressed in the root and in the shoot. {ECO:0000269|PubMed:12972670}.