LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP010172

UniProt Annotations

Entry Information
Gene Nameenoyl-[acyl-carrier-protein] reductase [NADH]
Protein EntryFABI_ARATH
UniProt IDQ9SLA8
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=288 uM for crotonyl-CoA {ECO:0000269|PubMed:18467464};
Catalytic ActivityAn acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.
Disruption PhenotypePremature cell death in several organs, chlorotic and curly leaves, semidwarfism, distorted siliques, premature senescence of primary inflorescences, reduced fertility and decrease in total lipid content. {ECO:0000269|PubMed:10715326}.
Enzyme RegulationInhibited by the phytotoxin cyperin and the synthetic antimicrobial compound triclosan. {ECO:0000269|PubMed:18467464}.
FunctionCatalyzes the NAD-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Catalyzes the last reduction step in the de novo synthesis cycle of fatty acids. Involved in the elongation cycle of fatty acids which are used in lipid metabolism. Required for normal plant growth. {ECO:0000269|PubMed:10715326, ECO:0000269|PubMed:18467464}.
PathwayLipid metabolism; fatty acid biosynthesis.
Sequence CautionSequence=AAG40070.1; Type=Frameshift; Positions=150; Evidence={ECO:0000305};
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast {ECO:0000305}.
SubunitHomotetramer. {ECO:0000250}.
Tissue SpecificityExpressed in flowers and siliques and at lower levels in roots and leaves (at protein level). {ECO:0000269|PubMed:10380806, ECO:0000269|PubMed:10715326}.