LIPID MAPS® Gene/Proteome Database (LMPD)

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LMP010763

UniProt Annotations

Entry Information

Gene Name	peroxin-16
Protein Entry	PEX16_ARATH
UniProt ID	Q8S8S1
Species	Arabidopsis

Comments

Comment type	Description
Developmental Stage	Up-regulated during seed maturation. {ECO:0000269\|PubMed:10195899}.
Disruption Phenotype	Not viable shrunken seeds. Starch accumulation in mature embryos, cotyledon and hypocotyl cells. Developmental delay during early embryo morphogenesis. {ECO:0000269\|PubMed:10195899}.
Domain	The internal domain (235-279) containing two internal membrane helices and the intervening residues that include the basic cluster VRS is sufficient for targeting recombinant proteins to endoplasmic reticulum and then to peroxisomes.
Function	Involved in the formation of peroxisomes, lipid bodies and protein bodies. {ECO:0000269\|PubMed:10195899, ECO:0000269\|PubMed:15173561, ECO:0000269\|PubMed:16896794, ECO:0000269\|PubMed:17431024, ECO:0000269\|PubMed:17478547}.
Miscellaneous	Travels from the cytosol to peroxisomes via the reticular and perinuclear endoplasmic reticulum (ER) and an ER- peroxisome intermediate compartment (ERPIC).
Ptm	The detection of an additional immunorelated polypeptide of 52 kDa suggests a post-translational modification of PEX16.
Similarity	Belongs to the peroxin-16 family. {ECO:0000305}.
Subcellular Location	Peroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Moves through an intermediate compartment from endoplasmic reticulum to pre-existing peroxisomes. {ECO:0000269\|PubMed:15173561, ECO:0000269\|PubMed:16040658, ECO:0000269\|PubMed:17431024}.
Tissue Specificity	Expressed in roots, siliques, seeds, cotyledons, leaves and flowers. Low expression in leaves and roots. {ECO:0000269\|PubMed:10195899, ECO:0000269\|PubMed:15173561, ECO:0000269\|PubMed:16040658}.