LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

LMP010813

UniProt Annotations

Entry Information

Gene Name	phosphatidylinositol transfer protein COW1
Protein Entry	SFH1_ARATH
UniProt ID	F4JLE5
Species	Arabidopsis

Comments

Comment type	Description
Disruption Phenotype	Exhibits short branched root hairs. {ECO:0000269\|PubMed:15546352, ECO:0000269\|PubMed:15728190, ECO:0000269\|PubMed:23456248, ECO:0000269\|PubMed:9390433}.
Function	Required for transport of secretory proteins from the Golgi complex (By similarity). Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Plays a role in root hair tip elongation as a key regulator of polarized membrane trafficking. May promote the PtdIns(4,5)P2 synthesis and organization in root hair membrane. {ECO:0000250, ECO:0000269\|PubMed:15546352, ECO:0000269\|PubMed:15728190, ECO:0000269\|PubMed:17335879, ECO:0000269\|PubMed:23456248, ECO:0000269\|PubMed:9390433}.
Sequence Caution	Sequence=CAA18837.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAE82296.1; Type=Frameshift; Positions=551; Evidence={ECO:0000305}; Sequence=CAE82297.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the SFH family. {ECO:0000305}.
Similarity	Contains 1 CRAL-TRIO domain. {ECO:0000255\|PROSITE- ProRule:PRU00056}.
Subcellular Location	Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000269\|PubMed:15728190}; Peripheral membrane protein {ECO:0000269\|PubMed:15728190}.
Tissue Specificity	Predominantly expressed in roots. Detected solely in root trichoblast cell files engaged in root hair growth, hydathodes, shoot apical meristem, and apical cells of the root cap. {ECO:0000269\|PubMed:15546352, ECO:0000269\|PubMed:15728190}.