LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP010833

UniProt Annotations

Entry Information
Gene Namephosphoethanolamine N-methyltransferase 1
Protein EntryPEAM1_ARATH
UniProt IDQ9FR44
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityS-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. {ECO:0000255|PROSITE-ProRule:PRU00915}.
Disruption PhenotypeAltered root development due to defect in primary root elongation and root epidermal cell development. {ECO:0000269|PubMed:15295103}.
FunctionCatalyzes N-methylation of phosphoethanolamine, phosphomonomethylethanolamine and phosphodimethylethanolamine, the three methylation steps required to convert phosphoethanolamine to phosphocholine. Required for root system development and epidermal cell integrity through its role in choline and phospholipid metabolism. {ECO:0000269|PubMed:15295103}.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from phosphoethanolamine: step 1/1.
Sequence CautionSequence=BAB02720.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. PEAMT family. {ECO:0000255|PROSITE- ProRule:PRU00915}.
Subcellular LocationCytoplasm {ECO:0000305}.