LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP010872

UniProt Annotations

Entry Information
Gene Namephospholipase D beta 1
Protein EntryPLDB1_ARATH
UniProt IDP93733
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Ca(2+). Requires micromolar level (PIP2-dependent).;
DomainC2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. In PLD beta, all the calcium-coordinating acidic amino acids are conserved.
Enzyme RegulationInhibited by neomycin.
FunctionHydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence. Can use phosphatidylserine or N-acylphosphatidylethanolamine as substrates.
InductionActivated by wounding, methyl jasmonate, heavy metal, osmotic and salt stresses.
Sequence CautionSequence=AAB63542.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC49656.2; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
SimilarityBelongs to the phospholipase D family. C2-PLD subfamily. {ECO:0000305}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular LocationCytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue SpecificityExpressed in stems, and to a lower amount in leaves, flowers and siliques.