LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP010902

UniProt Annotations

Entry Information
Gene Namephosphoethanolamine N-methyltransferase 2
Protein EntryPEAM2_ARATH
UniProt IDQ944H0
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q944H0-1; Sequence=Displayed; Name=2; IsoId=Q944H0-2; Sequence=VSP_053713;
Catalytic ActivityS-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. {ECO:0000255|PROSITE-ProRule:PRU00915}.
Disruption PhenotypeNo visible phenotype under normal growth conditions. {ECO:0000269|PubMed:20650897}.
FunctionCatalyzes N-methylation of phosphomonomethylethanolamine and phosphodimethylethanolamine, the two methylation steps required to convert phosphomonoethanolamine to phosphocholine. Unlike NMT1, NMT2 cannot utilize phosphoethanolamine as substrate in vitro. {ECO:0000269|PubMed:20650897}.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis.
Sequence CautionSequence=AAF79704.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF79705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. PEAMT family. {ECO:0000255|PROSITE- ProRule:PRU00915}.
Subcellular LocationCytoplasm {ECO:0000250}.