LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP010948

UniProt Annotations

Entry Information
Gene Name3-ketoacyl-CoA synthase 17
Protein EntryKCS2_ARATH
UniProt IDO65677
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Catalytic ActivityStearoyl-CoA + malonyl-CoA + 2 NAD(P)H = icosanoyl-CoA + CO(2) + CoA + 2 NAD(P)(+) + H(2)O.
Enzyme RegulationInhibited by K3 herbicides such as alachlor, allidochlor, anilofos, cafenstrole, fentrazamide and flufenacet. {ECO:0000269|PubMed:15277688}.
FunctionActive on saturated acyl-CoAs up to C22. Mediates the synthesis of VLCFAs from 20 to 26 carbons in length (e.g. C20:1, C20, C24, C26). {ECO:0000269|PubMed:15277688, ECO:0000269|PubMed:16765910}.
InductionRepressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the chalcone/stilbene synthases family. {ECO:0000305}.
SimilarityContains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.