LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP011094

UniProt Annotations

Entry Information

Gene Name	protein ECERIFERUM 3
Protein Entry	CER3_ARATH
UniProt ID	Q8H1Z0
Species	Arabidopsis

Comments

Comment type	Description
Disruption Phenotype	Plants show postgenital fusion between aerial organs and severe male sterility in low-humidity environments. Altered cuticular waxes, but no effect on cutin load and composition. {ECO:0000269\|PubMed:12724542, ECO:0000269\|PubMed:12974811, ECO:0000269\|PubMed:14756310, ECO:0000269\|PubMed:17624331}.
Function	Involved in cuticule membrane and wax production, and in the typhine and sopropollenin biosynthesis of pollen. Core components of a very-long-chain alkane synthesis complex. May be the fatty acid reductase responsible for aldehyde formation. {ECO:0000269\|PubMed:12724542, ECO:0000269\|PubMed:12974811, ECO:0000269\|PubMed:14756310, ECO:0000269\|PubMed:22773744}.
Sequence Caution	Sequence=AAK68765.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB08850.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the sterol desaturase family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:16618929, ECO:0000269\|PubMed:19892830}; Multi- pass membrane protein {ECO:0000269\|PubMed:16618929, ECO:0000269\|PubMed:19892830}. Note=PubMed:16618929 indicates a vacuole membrane localization.
Subunit	Interacts with CER1. {ECO:0000269\|PubMed:22773744}.
Tissue Specificity	Expressed in siliques, stems, flowers and weakly in leaves. Not detected in pollen, seeds and roots, but expressed in lateral root primordia. Specifically found in the L1 layer of the shoot apical meristem and in developing trichomes. {ECO:0000269\|PubMed:12724542, ECO:0000269\|PubMed:12974811, ECO:0000269\|PubMed:14756310, ECO:0000269\|PubMed:21386033}.