LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP011285

UniProt Annotations

Entry Information
Gene NameSNF1-related protein kinase catalytic subunit alpha KIN10
Protein EntryKIN10_ARATH
UniProt IDQ38997
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q38997-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q38997-2; Sequence=VSP_009001;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
Enzyme RegulationActivated by phosphorylation at Thr-198. {ECO:0000269|PubMed:19339507}.
FunctionCatalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase. In vitro, KIN10 exhibits kinase activity on sucrose phosphate synthase and the kinase activity is inhibited by PRL1. May be a subunit of a SCF ubiquitin ligase complex and thus be involved in proteasomal ubiquitination. Phosphorylates GRIK1/SNAK2 and GRIK2/SNAK1 in vitro. {ECO:0000269|PubMed:10220464, ECO:0000269|PubMed:11387208, ECO:0000269|PubMed:20164192}.
InductionInduced by sucrose. {ECO:0000269|PubMed:10220464}.
InteractionQ93V58:GRIK1; NbExp=2; IntAct=EBI-2107143, EBI-6399184; Q5HZ38:GRIK2; NbExp=2; IntAct=EBI-2107143, EBI-6399237; Q9SCY5:KINB2; NbExp=3; IntAct=EBI-2107143, EBI-2042436; Q42384:PRL1; NbExp=3; IntAct=EBI-2107143, EBI-1382964; Q944A6:SNF4; NbExp=2; IntAct=EBI-2107143, EBI-2360649;
PtmAutophosphorylated. Phosphorylated at Thr-198 by GRIK1/SNAK2 and GRIK2/SNAK1. {ECO:0000269|PubMed:10220464, ECO:0000269|PubMed:19339507}.
SimilarityBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. {ECO:0000305}.
SimilarityContains 1 KA1 (kinase-associated) domain. {ECO:0000255|PROSITE-ProRule:PRU00565}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 1 UBA domain. {ECO:0000255|PROSITE- ProRule:PRU00212}.
SubunitSubunit of a probable heterotrimeric complex consisting of an alpha catalytic (KIN10 or KIN11) subunit, and a beta (KINB) and a gamma (KING or SNF4) non-catalytic regulatory subunits. Interacts with KINB2, KINB3, SNF4 and probably with KINB1 and KING1. Interacts with SKP1/ASK1, PAD1, the N-terminus of PRL1 and the WD40 domain of 5PTase13. Potential subunit of a SCF ubiquitin ligase complex consisting of a SNF1-related protein kinase, SKP1 and CUL1. The association of the SCF complex with the proteasome may be mediated by PAD1 and seems to be inhibited by the interaction with PRL1. Interacts with DSP4. {ECO:0000269|PubMed:10220464, ECO:0000269|PubMed:10929106, ECO:0000269|PubMed:11387208, ECO:0000269|PubMed:11522840, ECO:0000269|PubMed:15803412, ECO:0000269|PubMed:18931139}.
Web ResourceName=PlantP kinase Classification PPC; URL="http://plantsp.genomics.purdue.edu/family/class.html";