LIPID MAPS® Gene/Proteome Database (LMPD)

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LMP011286

UniProt Annotations

Entry Information
Gene NameSNF1-related protein kinase catalytic subunit alpha KIN11
Protein EntryKIN11_ARATH
UniProt IDP92958
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P92958-1; Sequence=Displayed; Name=2; IsoId=P92958-2; Sequence=VSP_034567, VSP_034568; Note=Derived from EST data. No experimental confirmation available.;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
Enzyme RegulationInactivated by the begomovirus AL2 protein or the curtovirus L2 protein. Activated by phosphorylation at Thr- 176. {ECO:0000269|PubMed:12671096, ECO:0000269|PubMed:19339507}.
FunctionCatalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase. In vitro, KIN11 exhibits kinase activity on sucrose phosphate synthase and the kinase activity is inhibited by PRL1. May be a subunit of a SCF ubiquitin ligase complex and thus be involved in proteasomal ubiquitination. Involved in innate antiviral defenses. {ECO:0000269|PubMed:10220464, ECO:0000269|PubMed:11387208}.
InductionInduced by sucrose. {ECO:0000269|PubMed:10220464}.
InteractionQ9FEB5:DSP4; NbExp=2; IntAct=EBI-307202, EBI-307215; Q9SCY5:KINB2; NbExp=4; IntAct=EBI-307202, EBI-2042436; Q42384:PRL1; NbExp=2; IntAct=EBI-307202, EBI-1382964; Q9LVG2:TOE2; NbExp=2; IntAct=EBI-307202, EBI-4424568;
PtmAutophosphorylated. Phosphorylated at Thr-176 by GRIK1/SNAK2 and GRIK2/SNAK1. {ECO:0000269|PubMed:19339507}.
SimilarityBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. {ECO:0000305}.
SimilarityContains 1 KA1 (kinase-associated) domain. {ECO:0000255|PROSITE-ProRule:PRU00565}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 1 UBA domain. {ECO:0000255|PROSITE- ProRule:PRU00212}.
SubunitSubunit of a probable heterotrimeric complex consisting of an alpha catalytic (KIN10 or KIN11) subunit, and a beta (KINB) and a gamma (KING or SNF4) non-catalytic regulatory subunits. Interacts with KINB2, KINB3, SNF4 and probably with KINB1 and KING1. Interacts with SKP1/ASK1, PAD1 and the N-terminus of PRL1. Potential subunit of a SCF ubiquitin ligase complex consisting of a SNF1-related protein kinase, SKP1 and CUL1. The association of the SCF complex with the proteasome may be mediated by PAD1 and seems to be inhibited by the interaction with PRL1. Interacts with DSP4. Interacts with the begomovirus AL2 protein and the curtovirus L2 protein. {ECO:0000269|PubMed:10220464, ECO:0000269|PubMed:10417704, ECO:0000269|PubMed:10929106, ECO:0000269|PubMed:11387208, ECO:0000269|PubMed:11522840, ECO:0000269|PubMed:12148529, ECO:0000269|PubMed:12671096, ECO:0000269|PubMed:15803412}.
Tissue SpecificityExpressed in roots, shoots, flower buds, flowers, siliques and leaves. {ECO:0000269|PubMed:10417704}.
Web ResourceName=PlantP kinase Classification PPC; URL="http://plantsp.genomics.purdue.edu/family/class.html";