LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP011423

UniProt Annotations

Entry Information
Gene Nameubiquitin-like modifier-activating enzyme atg7
Protein EntryATG7_ARATH
UniProt IDQ94CD5
SpeciesArabidopsis
Comments
Comment typeDescription
Developmental StageUp-regulated during leaf senescence. {ECO:0000269|PubMed:12070171}.
DomainThe C-terminal residues are required for homodimerization, as well as the interactions with ATG3, ATG8 and ATG12. {ECO:0000250}.
DomainThe GxGxxG motif is important for the function, possibly through binding with ATP.
FunctionE1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. {ECO:0000269|PubMed:12070171}.
Sequence CautionSequence=BAB09318.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the ATG7 family. {ECO:0000305}.
SubunitHomodimer. Interacts with ATG8 through a thioester bond between Cys-558 and the C-terminal glycine of ATG8 and with ATG12 through a thioester bond between Cys-558 and the C-terminal glycine of ATG12. Interacts also with ATG3 (By similarity). {ECO:0000250}.
Tissue SpecificityConstitutively expressed (at protein level). {ECO:0000269|PubMed:12070171}.