LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP011724

UniProt Annotations

Entry Information
Gene Namecarbonyl reductase 4
Protein EntryCBR4_DANRE
UniProt IDQ6P0H7
SpeciesZebrafish
Comments
Comment typeDescription
FunctionThe heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (By similarity). {ECO:0000250}.
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitHomotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4 (Potential). {ECO:0000305}.