LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012321

UniProt Annotations

Entry Information
Gene NameAPC membrane recruitment protein 2
Protein EntryAMER2_DANRE
UniProt IDF1QGH6
SpeciesZebrafish
Comments
Comment typeDescription
FunctionNegative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). {ECO:0000250}.
SimilarityBelongs to the Amer family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}.