LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012373

UniProt Annotations

Entry Information
Gene Namelipoyl(octanoyl) transferase 2 (putative)
Protein Entry
UniProt IDA6NK58
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityOctanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein].
FunctionCatalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
MiscellaneousIn the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon- amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes
PathwayProtein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 1/2.
SimilarityBelongs to the LipB family
SimilarityContains 1 BPL/LPL catalytic domain
Subcellular LocationMitochondrion