LIPID MAPS® Gene/Proteome Database (LMPD)

Introduction | Overview of Interfaces | Browse | Search | Download

LMPD Record

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012438

UniProt Annotations

Entry Information
Gene Namesynaptophysin
Protein EntrySYPH_RAT
UniProt IDP07825
SpeciesRat
Comments
Comment typeDescription
DomainThe calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
FunctionPossibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)
InteractionP33535:Oprm1; NbExp=8; IntAct=EBI-976085, EBI-4392569; Q9QWI6-2:Srcin1 (xeno); NbExp=2; IntAct=EBI-976085, EBI-775607;
PtmUbiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
SimilarityBelongs to the synaptophysin/synaptobrevin family
SimilarityContains 1 MARVEL domain. {ECO:0000255|PROSITE- ProRule:PRU00581}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
SubunitHomohexamer or homotetramer. Interacts with SRCIN1 (By similarity)
Tissue SpecificityCharacteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.