LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012516

UniProt Annotations

Entry Information
Gene Namelysophospholipase I
Protein EntryLYPA1_RAT
UniProt IDP70470
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-protein + H(2)O = palmitate + protein.
FunctionHydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity)
SimilarityBelongs to the AB hydrolase superfamily. AB hydrolase 2 family
Subcellular LocationCytoplasm.
SubunitHomodimer
Tissue SpecificityUbiquitous. Detected at low levels in all tissues tested. {ECO:0000269|PubMed:8631810, ECO:0000269|PubMed:9644627}.