LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012518

Gene Information

Entrez Gene ID25522
Gene Nameprotein kinase C, zeta
Gene SymbolPrkcz
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045179 IEA:EnsemblCapical cortex
GO:0016324 IEA:EnsemblCapical plasma membrane
GO:0043203 IEA:EnsemblCaxon hillock
GO:0005911 ISS:UniProtKBCcell-cell junction
GO:0031252 IDA:RGDCcell leading edge
GO:0005737 IDA:RGDCcytoplasm
GO:0005829 IDA:RGDCcytosol
GO:0005768 IEA:UniProtKB-KWCendosome
GO:0070062 IEA:EnsemblCextracellular vesicular exosome
GO:0043231 IDA:RGDCintracellular membrane-bounded organelle
GO:0045121 IDA:RGDCmembrane raft
GO:0005815 IEA:EnsemblCmicrotubule organizing center
GO:0035748 IEA:EnsemblCmyelin sheath abaxonal region
GO:0005635 IEA:EnsemblCnuclear envelope
GO:0016363 IEA:EnsemblCnuclear matrix
GO:0048471 IDA:RGDCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0043234 IDA:RGDCprotein complex
GO:0005923 IEA:EnsemblCtight junction
GO:0071889 IPI:RGDF14-3-3 protein binding
GO:0005524 IDA:RGDFATP binding
GO:0043274 IPI:RGDFphospholipase binding
GO:0015459 IMP:RGDFpotassium channel regulator activity
GO:0019904 IPI:RGDFprotein domain specific binding
GO:0004672 TAS:RGDFprotein kinase activity
GO:0019901 IPI:RGDFprotein kinase binding
GO:0004697 IDA:RGDFprotein kinase C activity
GO:0004674 IDA:RGDFprotein serine/threonine kinase activity
GO:0008270 IEA:InterProFzinc ion binding
GO:0031532 IMP:RGDPactin cytoskeleton reorganization
GO:0031584 IMP:RGDPactivation of phospholipase D activity
GO:0032148 IMP:RGDPactivation of protein kinase B activity
GO:0016477 IMP:RGDPcell migration
GO:0007166 IMP:RGDPcell surface receptor signaling pathway
GO:0034613 IMP:RGDPcellular protein localization
GO:0032869 IMP:RGDPcellular response to insulin stimulus
GO:0030010 IMP:UniProtKBPestablishment of cell polarity
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0008286 IMP:RGDPinsulin receptor signaling pathway
GO:0035556 IDA:RGDPintracellular signal transduction
GO:0007616 IMP:RGDPlong-term memory
GO:0060291 IMP:UniProtKBPlong-term synaptic potentiation
GO:0051899 IMP:RGDPmembrane depolarization
GO:0060081 IMP:RGDPmembrane hyperpolarization
GO:0000226 IEA:EnsemblPmicrotubule cytoskeleton organization
GO:0043066 IDA:RGDPnegative regulation of apoptotic process
GO:0051346 IDA:RGDPnegative regulation of hydrolase activity
GO:0046627 IEA:EnsemblPnegative regulation of insulin receptor signaling pathway
GO:0050732 IEA:EnsemblPnegative regulation of peptidyl-tyrosine phosphorylation
GO:0031333 IEA:EnsemblPnegative regulation of protein complex assembly
GO:1990138 IEA:EnsemblPneuron projection extension
GO:0018105 IDA:RGDPpeptidyl-serine phosphorylation
GO:0001954 IMP:RGDPpositive regulation of cell-matrix adhesion
GO:0008284 IMP:RGDPpositive regulation of cell proliferation
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:2000463 IDA:UniProtKBPpositive regulation of excitatory postsynaptic membrane potential
GO:0046326 IMP:RGDPpositive regulation of glucose import
GO:0046628 IMP:UniProtKBPpositive regulation of insulin receptor signaling pathway
GO:2001181 ISS:UniProtKBPpositive regulation of interleukin-10 secretion
GO:2000667 ISS:UniProtKBPpositive regulation of interleukin-13 secretion
GO:0032753 ISS:UniProtKBPpositive regulation of interleukin-4 production
GO:2000664 ISS:UniProtKBPpositive regulation of interleukin-5 secretion
GO:0051092 IMP:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0051222 IMP:RGDPpositive regulation of protein transport
GO:0050806 IMP:RGDPpositive regulation of synaptic transmission
GO:2000553 ISS:UniProtKBPpositive regulation of T-helper 2 cell cytokine production
GO:0045630 ISS:UniProtKBPpositive regulation of T-helper 2 cell differentiation
GO:0051291 IPI:RGDPprotein heterooligomerization
GO:0070528 IMP:RGDPprotein kinase C signaling
GO:0072659 IEA:EnsemblPprotein localization to plasma membrane
GO:0006468 IDA:RGDPprotein phosphorylation
GO:0007165 IDA:RGDPsignal transduction
GO:0047496 IMP:RGDPvesicle transport along microtubule
KEGG Pathway Links
KEGG Pathway IDDescription
ko04062Chemokine signaling pathway
rno04062Chemokine signaling pathway
ko04144Endocytosis
rno04144Endocytosis
ko04390Hippo signaling pathway
rno04390Hippo signaling pathway
ko04910Insulin signaling pathway
rno04910Insulin signaling pathway
ko04151PI3K-Akt signaling pathway
rno04151PI3K-Akt signaling pathway
rno04611Platelet activation
ko04015Rap1 signaling pathway
rno04015Rap1 signaling pathway
ko04530Tight junction
rno04530Tight junction
ko04930Type II diabetes mellitus
rno04930Type II diabetes mellitus
REACTOME Pathway Links
REACTOME Pathway IDDescription
5953253Disease
5953651GPVI-mediated activation cascade
5953645Hemostasis
5953818Loss of Function of SMAD2/3 in Cancer
5953821Loss of Function of SMAD4 in Cancer
5953827Loss of Function of TGFBR1 in Cancer
5953824Loss of Function of TGFBR2 in Cancer
5953644Platelet activation, signaling and aggregation
5953816Signaling by TGF-beta Receptor Complex
5953819Signaling by TGF-beta Receptor Complex in Cancer
5953420Signaling by VEGF
5953381Signal Transduction
5953822SMAD2/3 MH2 Domain Mutants in Cancer
5953817SMAD2/3 Phosphorylation Motif Mutants in Cancer
5953820SMAD4 MH2 Domain Mutants in Cancer
5954545TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
5953826TGFBR1 KD Mutants in Cancer
5953828TGFBR1 LBD Mutants in Cancer
5953825TGFBR2 Kinase Domain Mutants in Cancer
5953823TGFBR2 MSI Frameshift Mutants in Cancer
5953419VEGFA-VEGFR2 Pathway
5953418VEGFR2 mediated cell proliferation