LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012573

UniProt Annotations

Entry Information
Gene Namemonoglyceride lipase
Protein EntryMGLL_RAT
UniProt IDQ8R431
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityHydrolyzes glycerol monoesters of long-chain fatty acids.
FunctionConverts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity)
MiscellaneousRequires non-ionic detergent for solubilization.
MiscellaneousShort-term inhibition causes analgesia, while long- term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity
PathwayGlycerolipid metabolism; triacylglycerol degradation.
SimilarityBelongs to the AB hydrolase superfamily. Monoacylglycerol lipase family
SubunitHomodimer
Tissue SpecificityUbiquitous. Highly expressed in adipose tissue, adrenal gland, ovary, heart, spleen, lung, skeletal muscle, kidney and testis. Highly expressed throughout the brain