LIPID MAPS® Gene/Proteome Database (LMPD)

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LMP012578

Record overview

LMPD IDLMP012578
Gene ID29328
SpeciesMacaca mulata (Rhesus monkey)
Gene Nameglutathione peroxidase 4
Gene SymbolGpx4
SynonymsPhgpx; gpx-4; snGpx; Gshpx-4;
Alternate namesphospholipid hydroperoxide glutathione peroxidase, nuclear; phospholipid hydroperoxide glutathione peroxidase, mitochondrial;
Chromosome7
Map Location7q11
EC Number1.11.1.12
SummaryThis gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
OrthologsView orthologs and multiple alignments for Gpx4

Proteins

phospholipid hydroperoxide glutathione peroxidase, nuclear isoform A precursor
Refseq ID:NP_058861
Protein GI:90903249
UniProt ID:P36970
mRNA ID:NM_017165
Length:197
RefSeq Status:
MSWGRLSRLLKPALLCGALAVPGLAGTMCASRDDWRCARSMHEFAAKDIDGHMVCLDKYRGCVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAF
PCNQFGRQEPGSNQEIKEFAAGYNVRFDMYSKICVNGDDAHPLWKWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPQVIEKDLPCYL
 
N
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2594
peptide sequence: 
MSWGRLSRLLKPALLCGALAVPGLA
 
phospholipid hydroperoxide glutathione peroxidase, nuclear isoform B
Refseq ID:NP_001034938
Protein GI:90903229
UniProt ID:Q91XR8
mRNA ID:NM_001039849
Length:253
RefSeq Status:
MGRAAARKRGRCRQRGRSPGGRRRREPGRQSPRKRPGPRRRRARARRRRRARPRRMEPIPEPFNPRPLLQDLPQTSNSHEFLGLCASRDDWRCARSMHEF
AAKDIDGHMVCLDKYRGCVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAFPCNQFGRQEPGSNQEIKEFAAGYNVRFDMYSKICVNGDDAHPLW
KWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPQVIEKDLPCYL