LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012595

UniProt Annotations

Entry Information
Gene Namemitochondrial trans-2-enoyl-CoA reductase
Protein EntryMECR_RAT
UniProt IDQ9Z311
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
CautionWas originally (PubMed:9795230) thought to be a nuclear protein that interact with nuclear receptor. However, it was shown later to be mitochondrial (PubMed:12654921), a function related to nuclear receptors being unsure. {ECO:0000305|PubMed:12654921, ECO:0000305|PubMed:9795230}.
FunctionOxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2- decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity)
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
Subcellular LocationMitochondrion .
SubunitHomodimer