LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012615

UniProt Annotations

Entry Information
Gene Namebranched chain ketoacid dehydrogenase kinase
Protein EntryBCKD_RAT
UniProt IDQ00972
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate.
FunctionCatalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
PtmAutophosphorylated.
SimilarityBelongs to the PDK/BCKDK protein kinase family
SimilarityContains 1 histidine kinase domain
Subcellular LocationMitochondrion matrix.
SubunitMonomer.