LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012655

UniProt Annotations

Entry Information
Gene Nameannexin A2
Protein EntryANXA2_RAT
UniProt IDQ07936
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Short; IsoId=Q07936-1; Sequence=Displayed; Name=Long; IsoId=Q07936-2; Sequence=VSP_000287;
DomainA pair of annexin repeats may form one binding site for calcium and phospholipid.
FunctionCalcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
MiscellaneousIt may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
PtmISGylated
SimilarityBelongs to the annexin family
SimilarityContains 4 annexin repeats
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane . Melanosome . Note=In the lamina beneath the plasma membrane.
SubunitHeterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with COCH (By similarity)
Web ResourceName=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/086";