LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012662

Gene Information

Entrez Gene ID	58852
Gene Name	nuclear receptor subfamily 1, group H, member 3
Gene Symbol	Nr1h3
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0004879	IEA:Ensembl	F	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000978	IEA:Ensembl	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	IEA:Ensembl	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003707	IEA:InterPro	F	steroid hormone receptor activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0044255	IEA:Ensembl	P	cellular lipid metabolic process
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0042632	IEA:Ensembl	P	cholesterol homeostasis
GO:0010887	IEA:Ensembl	P	negative regulation of cholesterol storage
GO:0050728	IEA:Ensembl	P	negative regulation of inflammatory response
GO:0043031	IEA:Ensembl	P	negative regulation of macrophage activation
GO:0090188	IEA:Ensembl	P	negative regulation of pancreatic juice secretion
GO:0045861	IEA:Ensembl	P	negative regulation of proteolysis
GO:0090341	IEA:Ensembl	P	negative regulation of secretion of lysosomal enzymes
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0010875	IEA:Ensembl	P	positive regulation of cholesterol efflux
GO:2000188	IEA:Ensembl	P	regulation of cholesterol homeostasis
GO:0070328	IEA:Ensembl	P	triglyceride homeostasis

KEGG Pathway Links

KEGG Pathway ID	Description
ko05160	Hepatitis C
rno05160	Hepatitis C
ko04932	Non-alcoholic fatty liver disease (NAFLD)
rno04932	Non-alcoholic fatty liver disease (NAFLD)
ko03320	PPAR signaling pathway
rno03320	PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953330	Gene Expression
5953833	Generic Transcription Pathway
5954147	Nuclear Receptor transcription pathway